解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The effects of modification of the levels of endogenous plasma insulin on intestinal epithelial cell proliferation were investigated in rats maintained by total parenteral nutrition (TPN) using either a TPN diet that was high in glucose, or a low glucose (hypocaloric) TPN diet and in orally fed rats (normal and sham o...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1993.sp003717
更新日期:1993-09-01 00:00:00
abstract::Experiments were performed to investigate the presence and nature of beta-adrenoceptors in blood vessels supplying the posterior capsule of the rabbit knee joint. Electrical stimulation of the posterior articular nerve (PAN) and close intra-arterial injection of adrenaline produced vasoconstriction which reversed to v...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1993.sp003711
更新日期:1993-09-01 00:00:00
abstract::The role of endothelium in the decreased contraction to phenylephrine in aorta of pregnant Wistar rats has been studied. Contractions in response to phenylephrine were significantly decreased in aortic rings from pregnant rats compared to those from non-pregnant rats. Pretreatment of the rings with indomethacin did no...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1993.sp003694
更新日期:1993-05-01 00:00:00
abstract::Preparations of isolated rat jejunal enterocyte and brush-border and basolateral membrane vesicles have been used to study the effects of a 15 min exposure of upper and mid-villus enterocytes to pancreatic glucagon on the initial, unidirectional phlorhizin-sensitive (brush border) transport of galactose and phlorhizin...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1993.sp003680
更新日期:1993-03-01 00:00:00
abstract::Growing lambs fed a diet containing NaHCO3 were made acidotic by intravenously infusing HCl at the rate of 1 mmol/min over a 4 h period. Acid infusion led to a fall in blood and urine pH and a prompt increase in urinary Ca excretion. This in turn led to a fall in plasma Ca concentration and a rise in parathyroid hormo...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1993.sp003676
更新日期:1993-03-01 00:00:00
abstract::In anaesthetized cats, it was possible to enhance the dynamic sensitivity to stretch of jaw muscle spindle primary afferents by electrical stimulation in the midbrain. This effect was taken to be due to excitation of dynamic fusimotor neurones and was used to identify fusimotor fibres as static or dynamic in recording...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1993.sp003667
更新日期:1993-01-01 00:00:00
abstract::Chronically hypoxic (CH) and normoxic control rats were used to assess the action of S9581, a water-soluble analogue of almitrine bismesylate. S9581 increased ventilation (Ve) by 34% in control and 20% in CH rats. During acute hypoxia Ve was raised and S9581 caused a further increase of 20% in both groups. Low doses o...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1992.sp003648
更新日期:1992-11-01 00:00:00
abstract::Latex beads coated with secretory immunoglobulin (IgA) instilled into mouse intestinal loops are taken up by M cells present in Peyer's patch follicle-associated epithelial tissue. Bead adsorption and uptake is greater at the edge compared with the apex of follicle domes. Coating beads with bovine serum albumin (BSA) ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1992.sp003662
更新日期:1992-11-01 00:00:00
abstract::In Helix aspersa, activation of the cerebral giant serotonin neurones (GSNs) evokes a biphasic, excitatory synaptic response in the M neurones of the buccal ganglia. Local application of serotonin to the current-clamped M neurones also evokes fast and slow depolarizing responses. The slow response is thought to be dep...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1992.sp003656
更新日期:1992-11-01 00:00:00
abstract::The results of this investigation demonstrate, using a position matching paradigm, that the ability of subjects to detect changes in the position of the proximal interphalangeal joint is impaired in patients with rheumatoid arthritis affecting this joint. In this group there is a systematic flexion bias in position ju...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1992.sp003633
更新日期:1992-09-01 00:00:00
abstract::To elucidate the regulatory role of atrial natriuretic factor (ANF) on vasopressin (AVP) and aldosterone release in conscious rabbits, ANF was administered systematically at a rate of 15 pmol min-1 (kg body wt)-1 for 15 min in two series of experimental animals in which AVP and/or aldosterone production was stimulated...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1992.sp003622
更新日期:1992-07-01 00:00:00
abstract::Measurements of intracellular calcium (Ca2+i) and sodium (Na+i) have been made in single smooth muscle cells in confluent cultures of the A7r5 cell line using the Ca(2+)- and Na(+)-sensitive dyes Fura-2 and sodium-binding benzofuran isophthalate (SBFI). Reversal of the Na+ gradient in control cells results in a small ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1992.sp003625
更新日期:1992-07-01 00:00:00
abstract::A recent model predicted a local synovial circulation of extravascular fluid in which capillary filtrate entered a joint cavity and fluid simultaneously drained out of the cavity via intercellular pathways distant from capillaries. Here, solutions of albumin (10-250 g l-1) were infused continuously into the knee joint...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1992.sp003613
更新日期:1992-05-01 00:00:00
abstract::Experiments were carried out to examine the perceived position of the human index finger about the proximal interphalangeal joint. In protocol I, the finger was moved from an intermediate position at velocities ranging from 200 deg/min to 2 deg/min, then held still at one of three positions. The subject's task was vis...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1992.sp003592
更新日期:1992-03-01 00:00:00
abstract::There is controversy about the effect of left ventricular pressure on resistance of the intramyocardial coronary vessels. In anaesthetized dogs the effect of left ventricular pressure on coronary flow during diastole was studied using an extracorporeal circulation and allowing the heart to contract and relax isovolumi...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1992.sp003602
更新日期:1992-03-01 00:00:00
abstract::The contribution of almitrine bismesylate to the occurrence and pattern of augmented breaths was studied in fifteen spontaneously breathing, anaesthetized cats. Breathing was via a tracheostomy, while the laryngeal resistance to airflow was measured with the larynx isolated in situ. Almitrine bismesylate at a dose of ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1992.sp003565
更新日期:1992-01-01 00:00:00
abstract::Rat hippocampal neurones in primary culture exhibited directional growth in response to DC electric fields. Neurites lay perpendicular to the field after exposure to 28, 80 or 219 mV/mm but there was no orientation effect at 9 mV/mm or in unexposed control cultures. Fields that evoked perpendicular responses also redu...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1992.sp003580
更新日期:1992-01-01 00:00:00
abstract::The effects of the bacterial toxin Escherichia coli STa on electrogenic secretion in proximal, mid and distal rat colon were examined in vitro using the short-circuit current (Isc) as an index of secretion. All areas showed toxin-elevated Isc which was reduced by bumetanide. The proximal colon was the most sensitive (...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1991.sp003561
更新日期:1991-11-01 00:00:00
abstract::Single cells from the rabbit pulmonary artery were isolated using a new and convenient procedure. Strips of muscle were incubated overnight in papain at 6 degrees C and dispersed the following morning after warming the tissue for 10 min. This method consistently produced a high yield of relaxed cells, which reversibly...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1991.sp003535
更新日期:1991-09-01 00:00:00
abstract::The effects on vasopressin and cortisol secretion of centrally and peripherally administered cholecystokinin octapeptide (CCK) were investigated in conscious prepubertal pigs. Injection of 1.3 micrograms CCK into the lateral cerebral ventricle resulted in a sustained increase in plasma vasopressin after a latency of 5...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1991.sp003518
更新日期:1991-07-01 00:00:00
abstract::Simultaneous portal blood absorption and intestinal mucosal catabolism of labelled fatty acids were investigated. Anaesthetized adult Wistar rats were infused intraduodenally either with 90 mumol of capric (C10:0), oleic (C18:1), linoleic (C18:2) or arachidonic (C20:4) 1-14C acids or with 30 mumol of each labelled fat...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1991.sp003511
更新日期:1991-05-01 00:00:00
abstract::It is commonly stated that smell elicits a parotid salivary reflex in humans. However, this assumption seems to be supported only by experiments in which either a lemon or an irritating odour has been used as the primary stimulus. In this study six pleasant odours, chocolate, vanilla, peppermint, beef, tomato and lemo...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1991.sp003502
更新日期:1991-05-01 00:00:00
abstract::The application of the four main techniques available for examining the properties of alpha-adrenoceptors, gene coding, radioligand, biochemical and functional methods, has reinforced the earlier subclassification (alpha 1- and alpha 2-subtypes). These different techniques have not yet yielded subclassifications which...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.1991.sp003501
更新日期:1991-05-01 00:00:00
abstract::The resonant frequency of the wrist has been measured in sixteen hypermobile and nine normal women at ten levels of peak torque. At the lowest level the results were identical but at the others the hypermobile values were lower. Damping and thixotropy appeared to be normal. In another group the grip strength of hyperm...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1991.sp003493
更新日期:1991-03-01 00:00:00
abstract::The effects of two different feeding regimes on the 24 h profiles of maternal and fetal plasma cortisol and adrenocorticotrophic hormone (ACTH) concentrations were studied in eight pregnant ewes between 123 and 144 days of gestation. Once daily-fed ewes (n = 4) received 1 kg of lucerne-chaff at 11.00 h, and multi-fed ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1991.sp003488
更新日期:1991-03-01 00:00:00
abstract::In quiescent papillary muscles isolated from hearts of rats with streptozotocin-induced diabetes resting intracellular sodium activity (aiNa) was about 56% greater than in muscles from controls. An intracellular acid load induced by the NH4+ method caused a rise in aiNa whose maximum amplitude was similar in both grou...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1991.sp003478
更新日期:1991-01-01 00:00:00
abstract::Endothelium-dependent relaxation in response to histamine and ACh has been studied on precontracted aortic rings from control and salt-loaded Sprague-Dawley rats. Both ACh and histamine caused relaxation of the noradrenaline-induced precontraction only in the presence of the endothelium. The relaxation response to ACh...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1991.sp003475
更新日期:1991-01-01 00:00:00
abstract::Plasma osteocalcin, or plasma bone GLA protein (BGP), total plasma alkaline phosphatase activity and urinary hydroxyproline excretion of twenty-four pregnant dairy cows (thirteen in their first or second pregnancy, i.e. low parity, and eleven in their third or more pregnancies, i.e. high parity) were measured from 7 w...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1990.sp003464
更新日期:1990-11-01 00:00:00
abstract::An investigation was made of the effects of H1 and H2 receptor agonists and antagonists on rabbit pancreatic exocrine secretion stimulated by secretin and cholecystokinin (CCK). The H1 agonist 2-thiazolylethylamine elicited dose-dependent increases in the rate of secretion. Increases in pancreatic juice flow and enzym...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1990.sp003444
更新日期:1990-09-01 00:00:00
abstract::Gastric motility was recorded from ferrets chronically prepared with an antral strain gauge. In fasted animals, antral motility showed cycles of activity and quiescence typical of the migrating motor complex (MMC) with a period of 44.7 +/- 6.1 min (n = 4). Anaesthesia with pentobarbitone sodium (50 mg/kg) disrupted th...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1990.sp003448
更新日期:1990-09-01 00:00:00
abstract::Rats were fed a liquid diet with the aim of decreasing nervous reflex activity in the parotid glands. In rats killed after 21 days on this diet the glands were atrophied and the total amounts of the neuropeptides, substance P, vasoactive intestinal peptide and calcitonin gene-related peptide, were lower than in contro...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1990.sp003435
更新日期:1990-07-01 00:00:00
abstract::The effect of the neuronal 5-HT3 receptor antagonist MDL 72222 has been investigated on the reflex tachypnoeic response to pulmonary embolism in pentobarbitone-anaesthetized rabbits. Pre-treatment with MDL 72222 (640 micrograms kg-1, 5 min prior to embolization) significantly attenuated the reflex tachypnoeic response...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1990.sp003424
更新日期:1990-07-01 00:00:00
abstract::Dipeptidylpeptidase IV (DPP IV) activity has been shown cytochemically to decrease significantly in enterocytes of children suffering from coeliac disease. This decrease is due to a halving of the time available for enterocytes to express DPP IV in their brush-border membranes during development. This effect is compar...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1990.sp003439
更新日期:1990-07-01 00:00:00
abstract::Intestinal secretion is enhanced by starvation in rats. The rectum from fed and 3-day-starved rats generates a basal electrogenic ion transfer (short-circuit current) in vitro which is mainly electrogenic Na+ absorption (amiloride-sensitive, 66-71%) with a small component of electrogenic chloride secretion (furosemide...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1990.sp003438
更新日期:1990-07-01 00:00:00
abstract::Plasma 2H accumulation was measured in six male volunteers after ingestion of drinks containing trace amounts of 2H2O. Subjects fasted overnight and remained seated at rest or exercised on a cycle ergometer at 42, 61 or 80% of their maximum oxygen uptake (VO2, max). The rate of plasma 2H accumulation was faster at res...
journal_title:Experimental physiology
pub_type: 临床试验,杂志文章
doi:10.1113/expphysiol.1990.sp003419
更新日期:1990-05-01 00:00:00
abstract::We have considered the manner in which data obtained with ion-selective electrodes should be evaluated. The potential difference recorded by such electrodes, with respect to a stable reference, is converted to a concentration by a non-linear transformation--the Nernst or Nikolsky equation. The mean and standard deviat...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1990.sp003393
更新日期:1990-03-01 00:00:00
abstract::Fluid and electrolyte movements across the ruminal epithelium of sheep were studied using the temporarily isolated rumen technique. The sheep were all subjected to the following treatments: (1) fed sheep (fed twice daily), after rumen emptying, received rumen contents from a fed sheep; (2) food-deprived sheep (two mea...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1990.sp003385
更新日期:1990-01-01 00:00:00